Publications

View Paper Carat

A Novel Amino Acid Composition Ameliorates Short-Term Muscle Disuse Atrophy in Healthy Young Men

Frontiers in Nutrition | July 10, 2019

Skeletal muscle disuse leads to atrophy, declines in muscle function, and metabolic dysfunction that are often slow to recover. Strategies to mitigate these effects would be clinically relevant. In a double-blind randomized-controlled pilot trial, we examined the safety and tolerability as well as the atrophy mitigating effect of a novel amino acid composition (AXA2678), during…

Carat View Paper

Publications

View Paper Carat

Nutrition and Nonalcoholic Fatty Liver Disease: Current Perspectives

Gastroenterology Clinics of North America | March 2020

Nonalcoholic fatty liver disease (NAFLD) pathogenesis and progression are complex, heterogeneous, and multifactorial. The human diet typically contains thousands of bioactive molecules that orchestrate a variety of metabolic and signaling processes in health and disease, comprising a natural combination approach. Although food composition varies widely, cumulative evidence suggests that specific dietary macronutrients and micronutrients can…

Carat View Paper

Publications

View Paper Carat

The Metabolic Basis of Nonalcoholic Steatohepatitis

Endocrinology, Diabetes & Metabolism, Special Issue: NASH | February 24, 2020

Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease and is associated with significant morbidity and mortality worldwide, with a high incidence in Western countries and non‐Western countries that have adopted a Western diet. NAFLD is commonly associated with components of the metabolic syndrome, type 2 diabetes mellitus and cardiovascular disease,…

Carat View Paper

Presentations

View Presentation Carat

Unique Composition of Endogenous Metabolic Modulators Reprograms Metabolic State and Impacts Markers of Inflammation and Fibrosis in NAFLD/NASH Cell Model Systems

Keystone Symposia | January 22-24, 2019

Dysregulation of metabolic, inflammation and fibrotic pathways are linked to NAFLD progression. Effective therapies may require coordinated combinatorial approach to address multifactorial pathology. One potential modality is via endogenous molecules, such as amino acids (AAs), which when optimally combined can elicit meaningful effects. AXA1125, comprised of 6 AAs (LIVRQNac), designed to target liver function, was…

Carat View Presentation

Presentations

View Presentation Carat

Development of an in vitro platform to predict and screen combinations of endogenous metabolic modulators capable of influencing muscle physiology

International Conference on Frailty and Sarcopenia Research (ICFSR) | March 11-13,2020

Background: Dysregulated metabolism contributes to muscle wasting which results in decreased quality of life and morbidity and mortality in aging and disease. We previously published that AXA2678, a composition of Endogenous Metabolic Modulators (EMMs) anchored by amino acids (AA), promotes maintenance of muscle mass, prevents muscle fat accumulation, decreases pro-inflammatory cytokines and promotes myogenic myokines…

Carat View Presentation

Posters

View Poster Carat

A Novel Composition of Endogenous Metabolic Modulators, AXA4010, Impacts Adhesion, Inflammation, and RBC Membrane Deformability in Preclinical Models of Sickle Cell Disease

American Society of Hematology (ASH) | December 7-10, 2019

Background: In sickle cell disease (SCD), red blood cell (RBC) sickling propagates hemolysis, inflammation, vascular and endothelial injury with associated disruption in metabolic pathways including nitric oxide depletion, oxidative stress and an increased anabolic and energetic demand due to high RBC turnover. These metabolic functions highlight the role of amino acid biology in blood health…

Carat View Poster

Posters

View Poster Carat

AXA1665, a Defined Composition of Endogenous Metabolic Modulators, But Not Dietary Protein Improves the Dysregulated Amino Acid Metabolism and Ammonia Disposal in Child–Pugh A and B Subjects

American Association for the study of liver disease (AASLD) | November 8-12, 2019

Dysregulated nitrogen (N) handling due to impaired ureagenesis and amino acid (AA) metabolism results in a distinct plasma AA profile (eg ↓BCAA, ↑AAA) with hyperammonemia and muscle wasting in cirrhosis. While protein supplementation is standard‐of‐care for cirrhotic patients, it carries the risk of hyperammonemia and hepatic encephalopathy due to the underlying defective N metabolism and…

Carat View Poster

Posters

View Poster Carat

Mechanistic insights into the multimodal effects of AXA1125 in T2D subjects with NAFLD

American Association for the study of liver disease (AASLD) | November 8-12, 2019

Background: Convergent dysregulation of metabolism, inflammation, and fibrosis appears to be central to NASH pathogenesis. Previously [Hepatology 68(1) Suppl, pg 67A: #106], we showed AXA1125, a unique composition of amino acids (LIVRQNac), positively impacted lipotoxicity, insulin resistance, inflammation and fibrosis markers in T2D subjects with NAFLD as evidenced by reductions in liver fat, HOMA‐IR, ALT,…

Carat View Poster

Posters

View Poster Carat

AXA1665, a Novel Composition of Amino Acids, Restores the Dysregulated Amino Acid Profile, Lowers Ammonia, and Improves Body Composition and Function in Child–Pugh Class A and B Subjects

The European Association for the Study of the Liver (EASL) | April 10-14, 2019

Background and Aims: Sarcopenia has emerged as an independent risk factor for important clinical outcomes in cirrhosis, including hepatic encephalopathy (HE). It is closely linked to protein-malnutrition and perturbation in amino acid metabolism. A late evening snack (LES), considered part of routine care, appears to improve quality-of-life parameters in cirrhotic patients. While protein supplementation is…

Carat View Poster