Endogenous Metabolic Modulators

Introduction : Biological Processes and Signaling Networks

EMMs encompass a broad set of molecular families, including amino acids, bile acids, other intermediary substrates and hormones. These master regulators and signaling agents operate through highly orchestrated networks of metabolic pathways, which have evolved over billions of years, and control the ability of cells and organs to:

  • Select fuel sources
  • Create biomolecules such as nucleic acids, proteins, lipids and carbohydrates
  • Sense the availability of nutrients
  • Eliminate waste products
  • Produce immune responses
  • Activate signaling pathways

Endogenous Metabolic Modulators

EMMs are a critical set of molecules that are fundamental to biology. They serve as master regulators and signaling agents for metabolic pathways throughout the body. EMMs encompass a broad set of molecular families, including amino acids and their derivatives.

Our EMM Compositions

Axcella is combining deep insights about complex diseases, health, biologies and pathways with recent advances in systems biology and machine learning to design novel multi-targeted EMM compositions. Our current generation of EMM compositions incorporate multiple amino acids and their derivatives in distinct ratios. Designed to target multiple biological pathways, our candidates have the potential to generate a synergistic effect. And, since the individual EMM constituents we utilize have a general history of safe use in certain therapeutics and food products, we have been able to rapidly test our EMM compositions in Clinical Studies.

In addition to their potential to support health, we believe EMM compositions have potential applications in:

  • Inflammatory diseases
  • Immune diseases
  • Metabolic diseases
  • Mitochondrial diseases
  • Muscle wasting/atrophy
  • Neuropathy

Single Target Approach

Traditional single-target mechanisms may only address an individual metabolic or disease node.

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Axcella’s Multi-Targeted Approach

EMM compositions may have a synergistic effect on multiple metabolic pathways related to disease and health.

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Therapeutic Potential of EMMs

EMMs fundamentally impact human biology, driving activity in a myriad of pathways. EMMs not only are able to support continued health within the body; certain EMMs can be leveraged to treat a variety of diseases.

Complex human diseases involve the dysregulation of multiple biological pathways that converge into distinct nodes. One example is nonalcoholic steatohepatitis (NASH). In NASH, the liver cannot metabolize lipids and carbohydrates properly, which leads to increased inflammation, and eventually, fibrotic scarring. Each of these disease nodes is influenced by dysregulation of specific pathways, which can result in a set of symptoms, morbidity and ultimately mortality.

Unlike single-target mechanisms, we believe EMM compositions anchored by amino acids can be designed to simultaneously target and influence multiple targets and pathways, providing the potential for a multifactorial approach to treat complex diseases.

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Learn how we employ knowledge, data, and systems biology to unlock the potential of EMMs.

Our sophisticated platform allows us to design novel compositions of amino acids and their derivatives in specific ratios for targeted biologies and pathways.

EMMs in NASH
Learn how we are unlocking the potential of EMMs